Symbol
Name
ID

Atp6ap2
ATPase, H+ transporting, lysosomal accessory protein 2
MGI:1917745

Phenotype annotations related to renal/urinary system

Darker colors indicate more annotations

Mouse Phenotypes

increased podocyte apoptosis

kidney cyst

kidney cortex cyst

kidney medulla cyst

decreased urine osmolality

increased urine pH

increased urine protein level

albuminuria

abnormal kidney collecting duct morphology

dilated kidney collecting duct

abnormal kidney cortex morphology

abnormal podocyte morphology

podocyte foot process effacement

abnormal renal glomerulus morphology

glomerulosclerosis

abnormal kidney development

abnormal metanephric mesenchyme morphology

abnormal metanephric ureteric bud development

abnormal nephrogenic zone morphology

abnormal renal tubule epithelium morphology

decreased kidney weight

small kidney

renal hypoplasia

abnormal nephron morphology

abnormal nephron morphogenesis

abnormal S-shaped body morphology

abnormal comma shaped body morphology

decreased nephron number

absent proximal convoluted tubule brush border

dilated renal tubule

renal cast

abnormal ureteric bud morphology

impaired branching involved in ureteric bud morphogenesis

decreased urine output

polyuria

Availability

Mouse Genotype

Atp6ap2^em1Nira/Y

Atp6ap2^tm1.1Aich/Atp6ap2^tm1.1Aich
Tg(Hoxb7-cre)5526Cmb/0 (conditional)

Atp6ap2^tm1.1Aich/Atp6ap2^tm1.1Aich
Tg(Six2-EGFP/cre)1Amc/0 (conditional)

Atp6ap2^tm1.1Aich/Atp6ap2⁺
Tg(Six2-EGFP/cre)1Amc/0 (conditional)

Atp6ap2^tm1.1Ics/Y
Tg(NPHS2-cre)295Lbh/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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